The glomerular endothelial cell coat is essential for glomerular filtration
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منابع مشابه
Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier
Glomerular endothelial cell (GEnC) fenestrations are analogous to podocyte filtration slits, but their important contribution to the glomerular filtration barrier has not received corresponding attention. GEnC fenestrations are transcytoplasmic holes, specialized for their unique role as a prerequisite for filtration across the glomerular capillary wall. Glomerular filtration rate is dependent ...
متن کاملGlomerular Filtration
PA Renal, Winter 2010 Dr. Dave Johnson, Instructor 432 Stella Maris [email protected] Suggested Reading: There is no assigned reading other than this handout. However, a good reference text if you would like to buy one is Koeppen and Stanton’s Renal Physiology, 4 edition, Mosby Elsevier, 2007, For this particular lecture (glomerular filtration), Chapter 3 is the reference chapter to read in this...
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Rhophilin-1 is a Rho GTPase-interacting protein, the biologic function of which is largely unknown. Here, we identify and describe the functional role of Rhophilin-1 as a novel podocyte-specific protein of the kidney glomerulus. Rhophilin-1 knockout mice were phenotypically normal at birth but developed albuminuria at about 2 weeks of age. Kidneys from severely albuminuric mice revealed widespr...
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The formation of urine is a process that begins with glomerular filtration and is greatly influenced by changes in renal hemodynamics. Selective filtration of the blood is possible because of the unique characteristics of the glomerulus and renal circulation. Many factors interact to maintain a consistent blood flow allowing filtration and urine formation to continue despite systemic changes in...
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The kidney filtration barrier is formed by the combination of endothelial cells, basement membrane and epithelial cells called podocytes. These specialized actin-rich cells form long and dynamic protrusions, the foot processes, which surround glomerular capillaries and are connected by specialized intercellular junctions, the slit diaphragms. Failure to maintain the filtration barrier leads to ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2011
ISSN: 0085-2538
DOI: 10.1038/ki.2011.58